To a medium non-stick skillet over medium heat, add ground beef, onion, hamburger seasoning, seasoned salt, and pepper. Cook, breaking up the beef, until no longer pink. Remove from heat and drain excess grease if necessary. Set aside.
Remove the biscuits from the can and place them on a clean work surface. Using a rolling pin, roll each biscuit to about 5-6 inches in diameter and ⅛-inch thickness.
Evenly distribute the ground beef mixture (about ¼ cup for each pie) onto one-half of each biscuit, leaving about a ¼-inch border of dough. Top each with ¼ cup shredded cheese and a tablespoon of pickles (if using).
Brush the edges of the biscuit with water. Fold the biscuit over the filling (stretching it to accommodate the filling), creating a half-moon shape. Crimp the edges together using a fork, ensuring a complete seal.
Preheat air fryer to 360°F.
Brush each hand pie with water and sprinkle each with ¼ teaspoon sesame seeds.
Spray the basket of your air fryer with nonstick cooking spray. Working in batches, place the hand pies in the basket.
Air fry at 360°F for 4 minutes. Turn over the hand pies and air fry for another 2 minutes, or until golden brown and completely cooked. Brush with melted butter.
Serve hot with ketchup and mustard.