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Cheesy Chicken Casserole

Cheesy Chicken Casserole is a savory, filling, and flavorful dish with seasoned chicken, sauteed onions, and lots of cheese.

Course Dinner, Main Course
Cuisine American
Keyword Cheesy Chicken Casserole
Prep Time 20 minutes
Cook Time 1 hour 8 minutes
Total Time 1 hour 28 minutes
Servings 6
Calories 981 kcal
Author Amanda Rettke--iamhomesteader.com



  • 6 large boneless, skinless chicken breasts
  • 1 tablespoon paprika
  • ½ teaspoon kosher salt
  • ½ teaspoon black pepper
  • ½ teaspoon garlic powder
  • 1 cup all-purpose flour
  • 6 tablespoons butter, divided

Cheese Sauce

  • 1 white onion, finely diced
  • 1 can (10.75 ounces) cream of chicken soup
  • 1 cup heavy cream
  • 2 cups sharp cheddar cheese, shredded and divided


  1. Preheat oven to 350°F. Spray a 9x13-inch baking dish with nonstick cooking spray. Set aside.


  1. In a small bowl combine paprika, salt, pepper, and garlic powder.

  2. Sprinkle seasoning mixture on both sides of the chicken breasts. Rub the mixture into each to ensure the chicken is evenly coated.

  3. Dredge the seasoned chicken in the flour, making sure to cover all sides, and set aside.
  4. In a large skillet over medium heat, melt 4 tablespoons of butter.

  5. Working in batches, add the chicken breasts to the pan. Cook 4 minutes on each side (or until browned and crispy). They might not be cooked through at this point.

  6. Add chicken to the prepared baking dish.

Cheese Sauce

  1. To the same skillet (remove any burnt bits) add diced onion and the remaining 2 tablespoons of butter. Saute for 5-8 minutes, or until translucent.

  2. Add the cream of chicken, heavy cream, and 1 cup of shredded cheese.

  3. Whisk to combine into a sauce.


  1. Pour the sauce over the chicken.
  2. Bake for 40 minutes. (Cooking time could vary, depending on the size of the chicken breasts.)

  3. Add remaining shredded cheese and cook 20 more minutes or until cheese is hot and bubbly and chicken is cooked through. Chicken is done when its internal temperature is 165°F.