In a large bowl, combine water, yeast, and sugar. Let the mixture rest for about 5 minutes, or until the yeast begins to bloom.
In a small bowl, whisk together the olive oil, garlic, salt, and Italian seasoning.
Pour half the oil mixture into the yeast mixture. Set the remaining oil mixture aside.
Add flour to the oil and yeast mixture. Stir to combine.
Add dough to a greased bowl and cover with a clean towel. Allow the dough to rest in a warm place for about 1 hour, or until it has doubled in size.
Preheat the oven to 450°F.
Pour the reserved oil mixture into the bottom of a 9x11-inch baking dish. Use a pastry brush to coat the bottom of the dish.
Transfer the risen dough to the baking dish. Work the dough to the edges. Use your fingers to create dimples in the dough.
Bake the bread for 12 minutes. Carefully remove from the bread from oven to add the toppings.
Top the partially baked bread with the pizza sauce, 1 cup of mozzarella cheese, pepperoni, then the remaining ½ cup of mozzarella cheese.
Bake for an additional 13-15 minutes, or until the cheese is hot and bubbly.