Cheesy Chicken Casserole is a savory, filling, and flavorful dish with seasoned chicken, sauteed onions, and lots of cheese. Try my Chicken and Rice Casserole for another cheesy chicken hotdish.

Cheesy Chicken Casserole Being Lifted Out of Pan
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Cheesy Chicken Casserole

This savory and hearty dish is going to be a staple in your rotation of dinner recipes. It starts with seasoned and pan-seared chicken breasts and ends with a cheese sauce and more cheese on top! All the flavorful parts of the recipe are added and baked in one dish, ready to dish up to satisfy even the hungriest of eaters.

Overhead Image of Cheese Chicken Casserole

Cheesy Chicken Casserole Ingredients

Chicken Breasts: Boneless, skinless chicken breasts work best in this recipe. I used large chicken breasts, so the baking time may have to be adjusted if you are using smaller pieces of chicken. The chicken is fully cooked when it reaches an internal temperature of 165°F.

Cheese Sauce: The cheese sauce is made with sauteed onions, and there is a lot of it! So, be sure to add some to your chicken breast and use some to dunk some french fries.

Adding Sauce to Cheese Chicken Casserole

Preparing the Chicken

This chicken ended up being so tender and juicy. To get it prepared, first, season the chicken breasts with the paprika, salt, pepper, and garlic powder mix. Rub the mixture into both sides of each chicken breast. Next, dredge each chicken breast in some flour, coating all sides. Set the chicken aside.

To pan-sear the chicken, melt 4 tablespoons of butter in a large skillet over medium heat. Cook each chicken breast for about 4 minutes on each side, or until browned and crispy. The chicken will probably not be cooked all the way through at this point. However, they will be baked to finish cooking them. Place the seared chicken into a 9×13-inch baking dish that has been sprayed with nonstick spray. 

Cut Into Cheesy Chicken Casserole Recipe

How to Make Cheesy Chicken Casserole

Once the chicken has been prepared and the sauce mixed together, it’s time to get this hotdish baked and on the table! Pour the cheese sauce over the tops of the chicken breasts that are in the baking dish. Bake at 350°F for about 40 minutes. (Again, baking times can vary depending on the size of chicken you use.)

After 40 minutes, sprinkle the remaining cup of shredded cheese over the top of the chicken. Bake for another 20 minutes, or until the cheese is hot and bubbly. Chicken is fully cooked when each chicken breast has an internal temperature of 165°F.

When serving, don’t forget to use all that cheese sauce that may have settled in the dish. Spoon some sauce over your chicken breast. Or, use it as a dipping sauce for some Roasted Potato Wedges.

Bite of Cheesy Chicken Casserole Recipe

More Casseroles

5 from 9 votes

Cheesy Chicken Casserole

Prep Time 20 minutes
Cook Time 1 hour 8 minutes
Total Time 1 hour 28 minutes
Cheesy Chicken Casserole is a savory, filling, and flavorful dish with seasoned chicken, sauteed onions, and lots of cheese.

Ingredients

Chicken

  • 6 large boneless, skinless chicken breasts
  • 1 tablespoon paprika
  • ½ teaspoon kosher salt
  • ½ teaspoon black pepper
  • ½ teaspoon garlic powder
  • 1 cup all-purpose flour
  • 6 tablespoons butter, divided

Cheese Sauce

  • 1 white onion, finely diced
  • 1 can (10.75 ounces) cream of chicken soup
  • 1 cup heavy cream
  • 2 cups sharp cheddar cheese, shredded and divided

Instructions

  • Preheat oven to 350°F. Spray a 9×13-inch baking dish with nonstick cooking spray. Set aside.

Chicken

  • In a small bowl combine paprika, salt, pepper, and garlic powder.
  • Sprinkle seasoning mixture on both sides of the chicken breasts. Rub the mixture into each to ensure the chicken is evenly coated.
  • Dredge the seasoned chicken in the flour, making sure to cover all sides, and set aside.
  • In a large skillet over medium heat, melt 4 tablespoons of butter.
  • Working in batches, add the chicken breasts to the pan. Cook 4 minutes on each side (or until browned and crispy). They might not be cooked through at this point.
  • Add chicken to the prepared baking dish.

Cheese Sauce

  • To the same skillet (remove any burnt bits) add diced onion and the remaining 2 tablespoons of butter. Saute for 5-8 minutes, or until translucent.
  • Add the cream of chicken, heavy cream, and 1 cup of shredded cheese.
  • Whisk to combine into a sauce.

Assembly

  • Pour the sauce over the chicken.
  • Bake for 40 minutes. (Cooking time could vary, depending on the size of the chicken breasts.)
  • Add remaining shredded cheese and cook 20 more minutes or until cheese is hot and bubbly and chicken is cooked through. Chicken is done when its internal temperature is 165°F.

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You can tag me at @iamhomesteader.

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Reader Comments

  1. 5 stars
    This was a quick, easy meal to throw together that my whole family ate! That is a hard task for a family of 6! We will definitely put this into rotation for our menu. We made rice for the side and the kids loved the extra sauce over it.

  2. Thank you dear Amanda! I ❤️ your recipes – but for some reason they no longer print for me. But thanks anyways! Lydia💜💥👍😄

    1. Sorry about that, Lydia! If you open them in a new browser, like google or chrome, they will print. It’s a known issue from Facebook and they don’t seem willing to fix it 🙁

  3. 5 stars
    So very good! My husband is always asking for me to make it. I do add about 16oz of frozen or fresh broccoli florets around the chicken before adding the sauce… there’s enough sauce for this. I also serve it with rice. So very good!❤️❤️

  4. I have made this once and am going to make it again tonight for my husband and myself. We loved it. I make so many of your recipes and have been pleased with all of them

  5. Can you substitute thighs or have a combination of breasts and thighs. What would that do to the cooking time

      1. Search dairy free homemade cream of mushroom soup for a dairy free option. I cant do any cream soups due to allergies but the dairy free vesion is way better then canned in taste as well.

  6. 5 stars
    I’ve already made this recipe TWICE since I found it. It’s a really great homecooked meal and it makes us (two people) lots of leftovers! It’s got a ton of flavor to it and is a pretty easy dish to put together. I also put broccoli florets on top of the chicken before I poured the sauce over and made sure to spread it well. It was easy to add vegetables in that way and was SUPER tasty. The recipe produces enough sauce for this. Thanks, IamHomesteader!

  7. Can I sub out the cream for half and half! I am making this later this evening, let me know soon! Thank you!

    1. You could, but I have not tested it specifically so can’t say if it will change texture/flavor at all. But, in theory it should work. 🙂

    2. It’s in the oven right now! It looks amazing! I can’t wait to try it. I know it’s gonna be good because every single recipe I get from you is unbelievably delicious! And my mother was a fantastic cook and I consider myself one also only because of my mother🤗 your recipes remind me of her. Thank you for your delicious recipes.

5 from 9 votes (3 ratings without comment)

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