Turkey Tetrazzini is the perfect recipe for leftover turkey that is mixed with a creamy sauce, topped with mozzarella cheese, and baked in one dish. If you prefer chicken, try my Chicken Tetrazzini recipe.


Turkey Tetrazzini With Steam in Casserole Dish

Turkey Tetrazzini

Look no further than this recipe to use up leftover Thanksgiving turkey. This rich and creamy comfort food is as easy to put together as it is delicious! Another bonus is that this recipe is a lot less messy than a classic homemade tetrazzini, but is still as creamy, cheesy, and flavorful! Be sure to check out more of my Leftover Turkey Recipes, too!

Turkey Tetrazzini in a Casserole Dish from Overhead

Turkey Tetrazzini Ingredients

This is a hearty dish that is comfort food at its finest! It pairs wonderfully with some homemade dinner rolls!

Turkey: Use up the cooked turkey from the holiday. Or, make your own roasted turkey to use in this recipe.

Cream of mushroom soup: You could make homemade condensed cream of mushroom soup. Cream of chicken soup would also work in this recipe.

Onion powder: Use storebought, or make your own homemade onion powder for this recipe.

Adding Cheese to Turkey Tetrazzini


For this dish, you are going to start by preparing your noodles. I like to use salted water because it adds flavor to the water, which is absorbed by the food. It also increases the boiling point of the water (increasing the temperature) and that makes your noodles cook better.

Al dente just means that the noodles are cooked until they are firm and chewy but not soft or soggy.  This is very important to pasta because it will continue to cook after being removed from the water.  Most of the boxes or bags that you buy pasta in will indicate how long to cook the noodles. 

Plate of Turkey Tetrazzini

How to Make Turkey Tetrazzini

This casserole is a wonderful meal to make because it not only tastes great, it is baked in one pan. So, get the oven preheated to 325°F and grease a 9×13-inch baking dish. (You could also use a large oven-safe skillet).

In a large bowl, combine the cubed turkey, cream of mushroom soup, sour cream, chicken broth, butter, parmesan cheese, salt, pepper, onion powder, garlic powder, and cayenne pepper. Mix until well combined and add the cooked spaghetti noodles. Pour it into the greased pan.

Top the casserole with the shredded mozzarella cheese and cover it with aluminum foil. Bake for 45 minutes, covered. Then, remove the foil, baking it for another 10-15 minutes, or until the cheese is hot and bubbly. Top with parsley and serve.

Can I Freeze Turkey Tetrazzini?

Yes! This is one of those meals you can prepare ahead of time and take it out when you are ready to eat it! You can cut it into individual portions or just freeze it all in the pan. To freeze the casserole, follow the instructions up to baking the dish. Cover it with aluminum foil, label and date it, and pop it in the freezer. Let it defrost in the refrigerator overnight when you are ready to bake it.

Fork Twirling Turkey Tetrazzini on a Plate

More Casseroles

5 from 4 votes

Turkey Tetrazzini

Prep Time 10 minutes
Cook Time 1 hour
Total Time 1 hour 10 minutes
Turkey Tetrazzini is the perfect recipe for leftover turkey that is mixed with a creamy sauce, all topped with mozzarella cheese and baked in one dish.


  • 1 box (16 ounces) spaghetti noodles, cooked al dente per package instructions
  • 3 cups turkey, roasted or cooked, cut into cubes
  • 2 cans (10.5 ounces each) condensed cream of mushroom soup
  • 2 cups sour cream
  • ½ cup chicken broth
  • ½ cup (1 stick / 113 g) unsalted butter, melted
  • ¼ cup parmesan cheese, grated
  • ½ teaspoon kosher salt
  • ½ teaspoon pepper
  • ¼ teaspoon onion powder
  • ¼ teaspoon garlic powder
  • teaspoon cayenne pepper


  • 2 cups (226 g) mozzarella cheese, shredded
  • 1 tablespoon fresh parsley, chopped for garnish


  • Preheat oven to 325ºF and cook spaghetti noodles al dente. Spray a 9×13-inch baking dish with nonstick spray.
  • In a large bowl combine turkey, cream of mushroom soup, sour cream, broth, butter, parmesan, salt, pepper, onion powder, garlic powder, and cayenne pepper. Mix until well combined.
  • Add cooked noodles and toss to combine.
  • Pour into prepared 9×13-inch baking dish. (You could also use a 12-inch oven-safe skillet.)
  • Top with shredded mozzarella cheese.
  • Cover with aluminum foil and bake 45 minutes.
  • Remove foil and bake an additional 10-15 minutes, or until cheese is hot and bubbly.
  • Top with parsley. Serve.

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Reader Comments

  1. 5 stars
    Very easy and delicious recipe. I didn’t have leftover turkey so I substituted cooked and seasoned ground turkey. Will be a regular recipe in my rotation.

  2. 5 stars
    Added cooked broccili, next time sliced mushrooms. Easy and makes a ton. This is the third recipe I have tried in a week. Asked for your cookbook for Mothers Day.

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